Chemokines and Receptors

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Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines. As a type of cytokine, chemokines stimulate the movement of specific white blood cells and attract them to areas of inflammation, helping the body fight infections, inflammatory conditions, and various diseases. They also help maintain the proper functioning of the immune system. 

Chemokines play a central role in the development and homeostasis of the immune system, as well as in the activation, differentiation, proliferation, and apoptosis of immune cells. In the tumor microenvironment (TME), chemokines released by immune, tumor, and tumor-associated cells attract different types of tumor-promoting and anti-tumor immune cells, influencing tumor progression and metastasis, and directly affecting immune responses. In addition to being known for mediating chemotaxis, chemokines are all approximately 8-10 kilodaltons in mass and have four cysteine residues in conserved locations that are key to forming their 3-dimensional shape.

Therapeutic strategies utilizing or targeting chemokines have been developed over the past decade, leading to the testing of numerous new drug candidates in clinical trials. Chemokines are highly redundant in binding to receptors, with the same receptor able to bind to different chemokines and vice versa. Therefore, simultaneously inhibiting chemokine and its receptor with the same physiological function can lead to healthier and longer-lasting therapeutic effects.


  • Various molecules, species, and tags
  • High bioactivity
  • High purity verified by SDS-PAGE
  • Highly stable and convenient for storage and transportation


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