Colony-Stimulating Factors and Receptors (CSFs)
200 products
Colony-stimulating factors (CSFs) are secreted glycoproteins that play a crucial role in blood cell production. These proteins bind to receptor proteins on the surfaces of hemopoietic stem cells, activating intracellular signaling pathways that stimulate cell proliferation and differentiation. CSFs primarily affect the formation of white blood cells, while erythropoietin is responsible for red blood cell formation.
CSFs are soluble and can transduce signals via paracrine, endocrine, or autocrine signaling. The primary colony-stimulating factors include CSF1, CSF2, and CSF3, also known as M-CSF, GM-CSF, and G-CSF, respectively.
Beta LifeScience offers a comprehensive range of recombinant proteins for each of the four key CSFs, each with distinct modes of action:
- GM-CSF (CSF2): Stimulates the proliferation of granulocytes, macrophages, eosinophils, and megakaryocytes (progenitor cells of platelets) at high doses.
- M-CSF (CSF1): Encourages macrophage colony formation.
- G-CSF (CSF3): Promotes granulocyte colony formation and, to a lesser extent, granulocyte-macrophage colonies.
- Multi-CSF (IL-3): Stimulates colony formation for a broad spectrum of blood cells.
