Co-inhibitory Receptors

Co-inhibitory receptors are essential targets in immunology, playing a key role in downregulating immune responses. These receptors, including PD-1, CTLA-4, LAG-3, and others, are widely studied for their involvement in cancer, autoimmune conditions, and infectious diseases.

Our Co-Inhibitory Receptors collection offers high-quality recombinant proteins, antibodies, and assay-ready reagents to support your advanced research needs. Whether you're studying checkpoint pathways or developing immunotherapy models, our products are designed for reliable performance and consistency.

Browse our selection to find co-inhibitory receptors for sale, validated for flow cytometry, ELISA, cell-based assays, and more.

Understanding Co-Inhibitory Receptors

Co-inhibitory receptors are critical components of immune regulation, ensuring that immune responses remain balanced and controlled. These molecules act as immune checkpoints, preventing overactivation of T cells and maintaining self-tolerance. In research and drug development, they are essential targets for understanding immune escape mechanisms and creating novel therapies.

What Are Co-Inhibitory Receptors?

Co-inhibitory receptors are surface proteins found on T cells that deliver inhibitory signals upon binding to their ligands. Their primary function is to downregulate immune activity, preventing tissue damage and autoimmunity. In cancer, pathogens, or chronic inflammation, these receptors can become dysregulated, making them valuable markers and targets in immune-based studies.

Key Co-Inhibitory Receptors in Immunology

Several co-inhibitory receptors are extensively studied due to their strong roles in immune modulation. Below are the most prominent targets in current research:

• PD-1 (Programmed Death-1): This receptor binds to PD-L1 and PD-L2 ligands to limit T cell function. It’s one of the most studied checkpoint molecules in cancer immunotherapy.
• CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4): CTLA-4 competes with CD28 for binding to B7 molecules on antigen-presenting cells, thereby dampening T cell activation.
• LAG-3 (Lymphocyte-Activation Gene 3): Involved in suppressing T cell proliferation and cytokine secretion. It often co-expresses with PD-1 during T cell exhaustion.
• TIM-3 (T-cell immunoglobulin and mucin-domain containing-3): Plays a regulatory role in immune tolerance and is a promising target in chronic infections and cancer.
• TIGIT (T cell immunoreceptor with Ig and ITIM domains): Found on activated T cells and NK cells; it inhibits immune response through competition with co-stimulatory pathways.

These molecules are essential for researchers studying T cell dysfunction, immune evasion, and therapeutic checkpoint inhibitors. Our catalog includes recombinant proteins, antibodies, and tagged constructs for each of these co inhibitory receptors, optimized for lab use.

Importance in Disease and Therapy

The role of co-inhibitory receptors in disease mechanisms has gained tremendous attention in both academia and biotech. In cancer, for example, tumors often exploit these checkpoints to suppress immune responses, allowing cancer cells to grow undetected. Therapies that block PD-1 or CTLA-4 have shown groundbreaking results in restoring anti-tumor immunity.

In autoimmune diseases, the failure of these inhibitory mechanisms leads to self-reactive T cells attacking normal tissues. Understanding how to restore or enhance inhibitory signaling can help develop targeted interventions.

In chronic viral infections like HIV or Hepatitis B, overexpression of co-inhibitory receptors leads to T cell exhaustion. By targeting these pathways, researchers hope to revive the immune system’s ability to fight persistent infections.

With the rising demand for precision-based therapies, reliable and consistent lab tools are crucial. That’s why Beta LifeScience offers a full line of co inhibitory receptors for sale, ensuring high-performance reagents that meet the needs of immunologists, oncologists, and molecular biologists alike.

Our Co-Inhibitory Receptor Product Range

Beta LifeScience offers a carefully curated range of co-inhibitory receptors and supporting reagents designed to accelerate research in immunology, oncology, and therapeutic development. Each product is tested for performance and consistency to support both basic research and advanced translational studies. Whether you're exploring T cell checkpoint pathways or developing immune-based therapies, our co inhibitory receptors for sale deliver quality you can trust.

From high-specificity antibodies to functional recombinant proteins, our catalog supports a wide array of applications including flow cytometry, ELISA, Western blot, and in vitro assays. If you're working on high-throughput screening, biomarker validation, or drug discovery, we provide ready-to-use solutions designed for speed, accuracy, and reliability.

Monoclonal and Polyclonal Antibodies

We provide both monoclonal and polyclonal antibodies against key co-inhibitory receptors, including PD-1, CTLA-4, LAG-3, TIM-3, and TIGIT. Each antibody is validated for its binding specificity and optimized for various applications such as immunohistochemistry, immunoprecipitation, and functional blocking assays.

• Monoclonal Antibodies: Ideal for applications requiring high specificity and consistency across experiments. These antibodies are produced from a single clone and target a specific epitope, ensuring reproducibility in high-sensitivity workflows.
• Polyclonal Antibodies: These offer broader epitope recognition and are excellent for detecting proteins with low expression levels or structural variation. Suitable for early-stage discovery and pathway validation studies.

Every antibody in our range undergoes strict quality control for performance, helping you achieve accurate and repeatable results in your immune checkpoint research.

Recombinant Proteins and Ligands

Beta LifeScience also offers premium-grade recombinant co inhibitory receptors and ligands that are essential for functional studies, binding assays, and therapeutic modeling. Our recombinant proteins are expressed in mammalian systems to ensure proper folding, glycosylation, and bioactivity.

• Recombinant Receptors: Available for all major targets, including soluble forms of PD-1, CTLA-4, and LAG-3. These are suitable for ligand binding studies, inhibitor screening, and immunological assays.
• Recombinant Ligands: We also supply key ligands such as PD-L1, CD80, and Galectin-9 for receptor interaction studies. Each ligand is rigorously tested for binding efficiency and purity (≥95%).

These proteins are available in various tags and concentrations, offering compatibility with diverse platforms including SPR, ELISA, and high-throughput assays.

Custom Solutions and Bulk Orders

For labs conducting large-scale or specialized projects, we provide custom production services and bulk supply options. Whether you need antibody labeling, isotype switching, or custom protein expression, our team will work closely with your protocols and project goals.

• Custom Antibody Services: Develop target-specific antibodies tailored to your application, including unique epitope selection and format customization.
• Bulk Protein Orders: Secure consistent batches of recombinant proteins for long-term use with reduced variability across experiments.
• Technical Support: Our scientific team offers dedicated support to help with product selection, assay development, and optimization.

All our co inhibitory receptors for sale are manufactured to meet the highest standards, supporting your research from initial discovery to advanced testing.

Applications of Co-Inhibitory Receptors in Research

Co-inhibitory receptors play a crucial role in regulating immune responses, making them central targets across several key research areas. Their involvement in immune checkpoint pathways has opened the door to major breakthroughs in both fundamental and translational studies.

• Cancer Immunotherapy: Co-inhibitory receptors like PD-1 and CTLA-4 are at the forefront of cancer research. Our reagents support studies that explore T cell exhaustion, immune escape mechanisms, and checkpoint blockade therapies.
• Autoimmune Disease Modeling: Studying the dysregulation of co-inhibitory signals helps researchers understand the pathogenesis of diseases like lupus, multiple sclerosis, and type 1 diabetes.
• Transplant Biology: Suppressing immune overactivation is critical in transplantation research. Co-inhibitory markers help assess graft acceptance, tolerance induction, and long-term transplant outcomes.
• Infectious Disease Research: Chronic infections such as HIV, HCV, and tuberculosis are often associated with upregulation of co-inhibitory molecules. Our products help decode immune evasion and T cell dysfunction in these contexts.

Whether you're conducting high-throughput screening or mechanistic analysis, Beta LifeScience provides validated, high-performance tools to support your work on co-inhibitory pathways.

Why Choose Beta LifeScience for Co-Inhibitory Receptors

When it comes to sourcing co-inhibitory receptors for sale, researchers choose Beta LifeScience for quality, consistency, and trust. Every product in our catalog is built to support accurate results and seamless integration into your workflow.

• Research-Grade Quality: All antibodies and recombinant proteins undergo strict validation for performance in multiple assay systems, ensuring high specificity and minimal background.
• Wide Target Selection: From PD-1 and CTLA-4 to emerging targets like VISTA and TIGIT, we offer a growing portfolio to meet evolving research needs.
• Custom Services: Need something unique? We provide tailored antibody production, protein engineering, and bulk supply solutions to support custom protocols and long-term projects.
  
• Rapid Shipping & Expert Support: We maintain ready stock and ensure quick turnaround on orders. Our expert technical team is also available to guide product selection and assay optimization.

At Beta LifeScience, we don’t just supply reagents—we support discoveries. Our co inhibitory receptors collection is designed to help you push forward confidently with accurate, reliable, and reproducible results.