Recombinant Human SNRPA Protein
Beta LifeScience
SKU/CAT #: BL-4666PS
Recombinant Human SNRPA Protein
Beta LifeScience
SKU/CAT #: BL-4666PS
Catalog No.: BL-4666PS
Product Overview
| Tag | His |
| Host Species | Human |
| Synonym | U1 small nuclear ribonucleoprotein A, U1 snRNP A, U1-A, U1A, SNRPA, Mud1. |
| Background | SNRPA associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is essential for splicing. The SNRPA protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and is involved in the coupling of splicing and polyadenylation. SNRPA binds stem loop II of U1 snRNA. SNRPA is the first snRNP to interact with pre-mRNA. This interaction is vital for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. |
| Description | SNRPA Human Recombinant expressed in SF9 is a glycosylated, polypeptide chain having a calculated molecular weight of 34 kDa. SNRPA is expressed with a -6x His tag at N-terminus and purified by unique purification methods. |
| Source | Sf9 |
| Purity | >95.0% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU per μg by the LAL method. |
| Formulation | SNRPA is supplied in 16mM HEPES buffer pH-7.6, 400mM NaCl and 20% glycerol. |
| Stability | Recombinant protein is stable for 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
