Where to Buy HBV and HCV Recombinant Antigens for Research

Researchers can source HBV and HCV recombinant antigens from Beta LifeScience’s dedicated hepatitis antigen collection and request current pricing, quantity, and availability through the Online Inquiry form. The collection includes HBV surface, core, e and X antigens alongside HCV Core, NS3, NS4, NS5 and combined antigen formats. Before requesting a quote, select the required viral target, genotype or subtype, protein region, expression host, tag, purity and intended application. These specifications help determine whether a catalog antigen meets the project requirements or whether semi-custom or fully custom production is more appropriate.

Looking for an HBV or HCV recombinant antigen? Browse hepatitis antigens by target, genotype, expression host and tag, or provide your requirements for pricing and availability.

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Why Source HBV and HCV Antigens from Beta LifeScience?

Beta LifeScience provides a focused collection for researchers who need to compare hepatitis antigens by viral target and production format. Its HAV, HBV, HCV, HDV and HEV antigen collection currently contains more than 200 recombinant proteins, including broad HCV coverage and multiple HBV antigen formats.

Available sourcing options include:

• HBV surface, core, e, X and Pre-S antigens
• HCV Core, NS3, NS4, NS5 and combined antigens
• Multiple HBV genotypes, subtypes and HCV genotypes
• E. coli, yeast, insect-cell, mammalian-cell and CHO-cell expression
• Full-length proteins and defined protein fragments
• His, GST, His-SUMO and other tagged formats
• Selected tag-free recombinant antigens
• Catalog, semi-custom and full-custom production routes
• Online quotation and technical inquiry support
• Project-specific quantity and scale evaluation

This combination allows researchers to begin with a ready-made antigen and move to semi-custom protein production or fully custom protein expression when the required genotype, sequence region, tag, host or formulation is unavailable in the catalog. Product-specific availability, documentation, scale, and lead time can be confirmed during quotation.

Quick HBV and HCV Antigen Selection Checklist

Before choosing a product, confirm:

1. Whether the project requires an HBV or HCV antigen
2. The specific antigen, such as HBsAg, HBcAg, HBeAg, Core, NS3, NS4 or NS5
3. The required viral genotype, subtype, strain or isolate
4. Whether a full-length protein or defined fragment is needed
5. The expressed amino-acid boundaries
6. The preferred expression system
7. Whether the tag and tag orientation are compatible with the assay
8. Required purity, formulation and quantity
9. Available QC documentation
10. Product-listed research applications

A target name alone may not identify the correct antigen. Two products labelled “HCV Core antigen,” for example, may contain different genotype sequences, amino-acid regions, tags or formulations.

Which HBV Recombinant Antigen Should You Select?

HBV surface, core and e antigens represent different parts of the virus and support different research questions. They should not be treated as interchangeable products.

HBsAg

HBsAg is the hepatitis B surface antigen. Beta LifeScience’s collection includes different HBsAg subtypes and formats, including adw, adr, adw2, ayw, Pre-S1 and Pre-S2 products. When selecting HBsAg, confirm whether the research requires a particular subtype, envelope region or expression host. Particle-like presentation, folding and post-translational processing may also influence product selection.

HBcAg

HBcAg represents the HBV core or capsid protein. Available products may differ by genotype, amino-acid range, tag and expression system. Some constructs are full length, while others contain a defined fragment. If the experiment depends on capsid assembly or a particular conformational feature, confirm whether the supplied construct and product format support that objective.

HBeAg

HBeAg is related to the HBV precore/core region but is distinct from HBcAg. Researchers should verify construct boundaries and product-specific antigenicity rather than substituting one antigen for the other.

Featured HBV Recombinant Antigens

These examples are provided for initial product comparison. Confirm the complete sequence, formulation, QC documentation, and application compatibility on the individual product page before ordering.

Which HCV Recombinant Antigen Should You Select?

HCV recombinant antigens include structural proteins, nonstructural proteins and combined formats. Selecting the correct antigen requires confirmation of both the target protein and the expressed sequence.

HCV Core antigen

Core is a structural protein commonly considered for antibody-binding, immunogenicity, and viral-protein research. Buyers should verify the genotype and amino-acid range because different Core fragments may present different epitopes.

HCV NS3 antigen

NS3 contains protease- and helicase-associated regions. The required construct depends on whether the project focuses on antibody recognition, protein interactions, or enzyme-related research.

A general NS3 antigen fragment should not automatically be considered an active protease. Functional studies require an appropriate domain composition, folding state, cofactors and relevant activity data.

HCV NS4 antigen

NS4A and NS4B are separate proteins with different biological roles. Confirm whether a product described as “NS4” represents NS4A, NS4B or a selected immunodominant sequence.

HCV NS5 antigen

HCV NS5 includes NS5A and NS5B. A general NS5 antigen may contain only selected immunodominant regions rather than a complete functional protein.

Researchers requiring polymerase-related experiments should confirm that the product contains an appropriate NS5B construct and relevant activity documentation.

Combined HCV antigens

Combined or chimeric HCV antigens may incorporate selected regions from Core, NS3, NS4 and NS5. These formats can be considered when broader epitope representation is required, but buyers should review the identity and boundaries of every included region.

Featured HCV Recombinant Antigens

For example, Recombinant NS5 HCV Genotype 2, BLIT-0546 contains HCV genotype 2 immunodominant regions and is listed at greater than 95% purity by SDS-PAGE. Its product page lists antibody ELISA, immunogen, and Western blot among its research applications. These specifications apply specifically to BLIT-0546 and should not be generalized to every HCV antigen.

These examples are provided for initial product comparison. Confirm the complete sequence, formulation, QC documentation, and application compatibility on the individual product page before ordering.

Compare additional targets, genotypes and expression formats:

• Browse HBV and HCV Antigens
• Request Pricing and Availability

Research-use notice: Beta LifeScience recombinant antigens are supplied for research use only and are not intended for diagnostic or therapeutic use unless explicitly stated otherwise on the individual product page.

How Does Expression Host Affect Antigen Selection?

The expression host can affect folding, solubility, post-translational modification, and antigen presentation. It should therefore be evaluated alongside sequence and antigen identity.

E. coli expression

E. coli is widely used for recombinant viral-antigen production and can support many non-glycosylated proteins and defined antigen fragments.

Before selecting an E. coli-expressed antigen, review:

• Solubility and refolding information
• Endotoxin specifications where relevant
• Buffer composition
• Whether eukaryotic modifications are required
• Product-specific antigenicity or activity data

Yeast expression

Yeast supports eukaryotic protein expression and may be used for selected envelope or polyprotein constructs. Yeast glycosylation differs from mammalian glycosylation, so its compatibility should be evaluated against the intended application.

Insect-cell expression

Insect cells can support protein folding and processing that may be difficult to achieve in bacterial systems. Beta LifeScience lists several insect-cell-expressed HBV core and capsid proteins in both tagged and tag-free formats.

Mammalian and CHO-cell expression

Mammalian and CHO-cell systems may be considered when mammalian folding or post-translational processing is important. However, the expression host alone does not establish native biological behavior or application suitability. Construct design, purification and validation remain important.

Specifications to Check Before Requesting a Quote

Viral target and sequence

Confirm the antigen name, genotype, subtype, isolate and expressed amino-acid boundaries. For combined HCV antigens, check every included sequence region.

Protein tag

His, GST and SUMO tags can assist purification, detection or immobilization, but they also affect molecular weight and may influence some assay formats. Verify the tag type, orientation and whether tag-free material is required.

Protein purity

Check the reported purity percentage and analytical method, such as SDS-PAGE or HPLC. Purity does not independently establish antigenicity, biological activity or suitability for a specific assay.

Formulation and concentration

Confirm whether the protein is supplied as a liquid or lyophilized powder. Review the buffer, glycerol, salts, urea, reducing agents, and preservatives for compatibility with the downstream workflow.

QC documentation

Ask which product-specific documentation is available, including:

• Certificate of Analysis
• SDS-PAGE results
• Protein concentration
• Molecular-weight information
• Lot-specific specifications
• Storage and reconstitution instructions
• Antigenicity or activity testing, when offered

Quantity and supply planning

Include the initial quantity and possible future scale in the inquiry. This allows the supplier to confirm current availability and discuss bulk or project-specific repeat-supply planning.

Catalog, Semi-Custom or Full-Custom Production?

A catalog antigen is the most direct route when its genotype, sequence, host, tag, and formulation match the project. Semi-custom protein production can be considered when an existing protein needs modification, such as a different tag, host, sequence range, formulation, or endotoxin specification.

Full custom protein expression may be appropriate when the project requires:

• A different HBV subtype or HCV genotype
• A specific strain, isolate or mutation
• New construct boundaries
• An alternative expression host
• Tag addition, removal or relocation
• A custom formulation
• Project-specific QC
• Larger production quantities

Feasibility, included services, documentation, scale, timeline and pricing should be confirmed in the formal quotation.

How to Request and Order an HBV or HCV Antigen

Follow these steps to start an order or technical evaluation:

1. Search the HBV and HCV antigen collection by target, genotype, host or tag.
2. Review the complete product page, including sequence, expression system, purity, formulation, and storage information.
3. Record the catalog number and required quantity.
4. Submit the Online Inquiry form to request current pricing and availability.
5. Review Beta LifeScience’s How to Order page for purchasing and payment information.
6. If a catalog product does not meet the requirements, review the Custom Protein Expression service.
7. Submit the sequence and technical requirements through the Project Evaluation form.

Include the intended application, target antigen, genotype or subtype, sequence boundaries, expression-host preference, tag, quantity, purity, and formulation requirements. More complete project information supports a more relevant technical evaluation and quotation.

FAQs:

Where can researchers source HBV and HCV recombinant antigens?

Researchers can source HBV and HCV recombinant antigens through Beta LifeScience’s hepatitis antigen collection. Pricing and current availability can be requested through the Online Inquiry form.

Which HBV recombinant antigen should I choose?

Choose according to the research target. HBsAg represents surface antigen, HBcAg represents core or capsid antigen, and HBeAg represents the e antigen. Confirm subtype, sequence, host, tag and product-specific application information before ordering.

Which HCV antigen should I select for antibody research?

Core, NS3, NS4 and NS5 antigens represent different HCV regions. Selection depends on the target epitope, genotype, expressed sequence and experimental format. Combined antigens may be considered when broader sequence representation is required.

Can I request a different genotype, tag or protein region?

Yes. If the required configuration is unavailable in the catalog, submit the genotype, sequence, construct boundaries, host, tag, quantity and QC requirements for semi-custom or fully custom production evaluation.

How can I request HBV or HCV antigen pricing?

Submit the catalog number, quantity, and application requirements through the Online Inquiry form. Pricing, availability, documentation and lead time can then be confirmed for the selected product or project.

Find an HBV or HCV Antigen and Request a Quote

Start with a catalog antigen that matches your viral target, genotype, and research requirements. If the required sequence, host, tag, or formulation is unavailable, submit the project for a custom-production evaluation.

Send the antigen name, genotype or subtype, sequence region, expression host, tag, required quantity, and intended application to receive current availability and project-specific pricing.

• Browse HBV and HCV Antigens
• Request Pricing and Availability
• Submit a Custom Protein Project