Recombinant Human IL-13 Protein, Active, Low Endotoxin

Beta LifeScience SKU/CAT #: BEP-0056UL
Recombinant Human IL-13 (2 μg/lane) on SDSPAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a single band at 15 kDa and purity greater than 98%. and purity greater than 98%.
Recombinant Human IL-13 (2 μg/lane) on SDSPAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a single band at 15 kDa and purity greater than 98%. and purity greater than 98%.

Recombinant Human IL-13 Protein, Active, Low Endotoxin

Beta LifeScience SKU/CAT #: BEP-0056UL
/
Size

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Product Overview

Product Name Recombinant Human IL-13 Protein
Target Symbol IL13
Alternative Names Interleukin 13, IL13, P600, NC30, MGC116786, MGC116788, MGC116789
Accession Number AAK53823
Expression System E. coli.
Molecular Weight 12.7 kDa (predicted)
Sequence Ser19-Asn132, with an N-terminal Met
Purity >98% by SDS-PAGE and quantitative densitometry by CoomassiePurity ® Blue staining
Activity Determined by a cell proliferation assay using human TF-1 cells. The ED50 for this effect is typically <2 ng/mL
Formulation Lyophilized from sterile PBS with Trehalose, pH 7.4
Endotoxin Level <0.005 EU per 1 μg of the protein as determined by the LAL method
Shipping Shipped at ambient temperature.
Stability & Storage 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution Reconstitute at 100 ug/mL in sterile PBS.
Target Function Interleukin-13 (IL-13) is a cytokine primarily produced by T helper type 2 (Th2) cells, as well as other immune cells like mast cells, basophils, and eosinophils. It promotes the activation, differentiation, and survival of B cells, including Ig class switching. IL-13 enhances the survival and migration of epithelial cells in various organs, coupling this with its anti-parasitic Th2-mediated response in these organs. IL-13 signaling occurs when it binds IL13RA1 (CD213A1) which heterodimerizes with IL-4R alpha (CD124) to activate the JAK/STAT signal pathway.
Tissue Specificity IL-13 expression has been identified in gastrointestinal and lung epithelial tissue.
Cellular Localization Secreted protein
Involvement In Disease Dysregulation of IL-13 is associated with asthma, allergic rhinitis, atopic dermatitis, scleroderma, inflammatory bowel disease (IBD), and allergic conjunctivitis.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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