Recombinant Mouse NOTCH1 Protein (ECD, Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3545
Recombinant Mouse NOTCH1 Protein (ECD, Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3545
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | Fc |
Host Species | Mouse |
Accession | NP_032740.3 |
Synonym | 9930111A19Rik, lin-12, Mis6, N1, Tan1 |
Background | NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair regeneration of skeletal muscles.NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL).The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.The proto-oncogene NOTCH1 is frequently mutated in around 1% of patients with chronic lymphocytic leukemia (CLL). NOTCH1 mutations in oral squamous cell carcinoma (OSCC) frequently occur near the ligand-binding region. These mutations change the domain structure of this protein and affect the ligand binding activity. When NOTCH1 is activated by ligand binding, NOTCH1 intracellular domain (NICD) is cleaved from the cell membrane. |
Description | A DNA sequence encoding the mouse Notch1 (NP_032740.3) (Met1-Gln526) was expressed with the Fc region of human IgG1 at the C-terminus. |
Source | CHO Stable Cells |
Predicted N Terminal | Ala 19 |
AA Sequence | Met1-Gln526 |
Molecular Weight | The recombinant mouse Notch1 consists 749 a.a. and predicts a molecular mass of 80.6 kDa. |
Purity | >90% as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |