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| tag | GST |
| host species | Mouse |
| accession | NM_023913 |
| synonym | Ire1a; Ire1p; C85377; AI225830; Ire1alpha; 9030414B18Rik |
| background | ERN1 or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells (1). The activation of ERN1 through oligomerization expands the mechanistic repertoire of kinase-based signaling receptors. ERNI has a critical function in extraembryonic cells that is essential for fetal viability (2). |
| description | Recombinant mouse ERN1 (IRE1) (469-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. |
| source | Sf9 insect cells |
| AA sequence | 469a.a.-end |
| molecular weight | 87 kDa |
| purity | For specific purity information on a given lot, see related COA. |
| endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| bioactivity | Active |
| formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| stability | The recombinant protein is stable for up to 12 months at -70℃ |
| usage | For Research Use Only |
| storage | Recombinant Mouse ERN1 (IRE1) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Cat No. | Product Name | Source | Detail | Inquiry |
| BL-0060SG | Recombinant Human ERN1 (R727A) Protein | Sf9 insect cells |  |
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| BL-0061SG | Recombinant Human ERN1 (R728A) Protein | Sf9 insect cells | |
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| BL-0458SG | Recombinant Human ERN1 (IRE1) Protein | Sf9 insect cells | |
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