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Recombinant Human TRAIL R2 Protein (His&Fc Tag)

Cat No.: BL-2123NP
Description Related products
tag His&Fc
host species Human
accession O14763
synonym Tumor Necrosis Factor Receptor Superfamily Member 10B; Death Receptor 5; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TRAIL Receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9
background TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
description Recombinant Human TNF-Related Apoptosis-Inducing Ligand Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ile56-Glu182 is expressed with a Fc, 6His tag at the C-terminus.
source Human Cells
AA sequence Ile56-Glu182
purity >95% as determined by reducing SDS-PAGE.
endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
bioactivity Contact us for detailed information
formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
stability Recombinant Human TRAIL R2 protein is stable for 1 year at -70℃
reconstitution Dissolve the lyophilized protein in distilled water.
usage For Research Use Only
storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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