Recombinant Cynomolgus PD-L1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3740
Recombinant Cynomolgus PD-L1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3740
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Cynomolgus |
Accession | XP_015292694.1 |
Synonym | PD-L1 Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1 |
Background | CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers. |
Description | A DNA sequence encoding the cynomolgus/rhesus CD274 (XP_015292694.1) (Met1-Thr239) was produced with a His tag at the C-terminus. Cynomolgus and Rhesus CD274 sequences are identical. |
Source | HEK293 |
Predicted N Terminal | Phe 19 |
AA Sequence | Met1-Thr239 |
Molecular Weight | The recombinant cynomolgus/rhesus CD274 comprises 232 amino acids and has a calculated molecular mass of 26.7 KDa. |
Purity | Greater than 95% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Measured by its binding ability in a functional ELISA.Immobilized Cynomolgus CD274-His at 10 ug/ml (100 ul/well) can bind Cynomolgus PDCD1-Fc, The EC50 of Cynomolgus PDCD1-Fc is 1.0-2.3ug/ml. |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | Recombinnat Proteins are stable for up to 1 year from date of receipt at -70°C |
Usage | For Research Use Only |