Recombinant Rhesus HER3 / ERBB3 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2420
Recombinant Rhesus HER3 / ERBB3 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2420
Catalog No.: BLPSN-2420
Product Overview
| Tag | Fc |
| Host Species | Rhesus |
| Accession | XP_001113953.2 |
| Synonym | ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK |
| Background | Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2.ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and Erythroleukemia, Familial. Among its related pathways are PI3K/AKT activation and RET signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERBB4. |
| Description | A DNA sequence encoding the Rhesus (Macaca mulatta) ErbB3 (XP_001113953.2) extracellular domain (Met 1-Thr 643) was fused with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Ser 20 |
| AA Sequence | Met 1-Thr 643 |
| Molecular Weight | The recombinant Rhesus ErbB3/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 865 amino acids and predicts a molecular mass of 95.7 kDa. As a result of glycosylation, rhesus ErbB3/Fc monomer migrates as an approximately 130-140 kDa band in SDS-PAGE under reducing conditions. |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | 1. Measured by its ability to human NRG1 (aa 20-241) in functional Elisa.2. Measured by its ability to human NRG1 (aa 177-241) in functional Elisa.3. Measured by its ability to human NRG1 (aa 20-241)-His in functional Elisa. |
| Formulation | Recombinant Rhesus HER3 / ERBB3 Protein (Fc Tag) was lyophilized from sterile PBS, pH 7.4 |
| Stability | Recombinant Rhesus HER3 / ERBB3 protein is stable up to 1 year at -70°C |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
