Recombinant Rat TROP2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4676

Recombinant Rat TROP2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4676
Catalog No.: BLPSN-4676
Product Overview
Tag | His |
Host Species | Rat |
Accession | NP_001009540.2 |
Background | TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. |
Description | A DNA sequence encoding the rat TACSTD2 (NP_001009540.2) (Met1-Gly270) was expressed with a His tag at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Gln 20 |
AA Sequence | Met1-Gly270 |
Molecular Weight | The recombinant rat TACSTD2 consists of 257 a.a. and predicts a molecular mass of 29.5 kDa. |
Purity | >90% as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |