Name: Recombinant Rat FSTL1 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-2160
Availability: InStock

Catalog No.: BLPSN-2160

Product Overview

Tag	His
Host Species	Rat
Accession	NP_077345.1
Background	Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 1 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.
Description	A DNA sequence encoding the rat Fstl1 (NP_077345.1) (Met1-Ile306) was expressed with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Glu 19
AA Sequence	Met1-Ile306
Molecular Weight	The recombinant rat Fstl1 consists 299 a.a. and predicts a molecular mass of 34 kDa.
Purity	>90% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU per μg protein as determined by the LAL method.
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4..
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.