Recombinant Mouse WIF1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4855
Recombinant Mouse WIF1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4855
Catalog No.: BLPSN-4855
Product Overview
| Tag | His |
| Host Species | Mouse |
| Accession | Q9WUA1 |
| Synonym | AW107799, WIF-1 |
| Background | WIF1, also known as WIF-1 and wnt inhibitory factor 1, is a secreted protein which binds WNT proteins and inhibits their activities. It contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 may be involved in mesoderm segmentation and can be detected in fish, amphibia and mammals. WIF-1 is a recurrent target in human salivary gland oncogenesis. Downregulation of WIF1 takes part in the development and progression of pleomorphic adenomas. WIF1 also is a tumor suppressor, and has been found to be epigenetically silenced in various cancers, specifically in nonfunctioning pituitary tumors. WIF1 are expected to have molecular function (protein tyrosine kinase activity) and to localize in various compartments (extracellular space, extracellular region). |
| Description | A DNA sequence encoding the mouse WIF1 (Q9WUA1) (Met1-Trp379) was expressed with a C-terminal His tag. |
| Source | HEK293 |
| Predicted N Terminal | Gly 29 |
| AA Sequence | Met1-Trp379 |
| Molecular Weight | The recombinant mouse WIF1 comprises 362 a.a. and has a predicted molecular mass of 39.8 kDa. The apparent molecular mass of the protein is approximately 44 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| Purity | >93% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
