Name: Recombinant Mouse VE-Cadherin Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-4768
Availability: InStock

Recombinant Mouse VE-Cadherin Protein (His Tag)

Catalog No.: BLPSN-4768

Product Overview

Tag	His
Host Species	Mouse
Accession	NP_033998.2
Synonym	7B4, AA408225, Cd144, VE-Cad, Vec, VEcad, VECD
Background	Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
Description	A DNA sequence encoding the mouse CDH5 (NP_033998.2) extracellular domain (Met 1-Ala 592) was fused with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Gly 25 & Asp 46
AA Sequence	Met 1-Ala 592
Molecular Weight	The recombinant mouse CDH5 comprises 559 (mature form) or 580 (pro form) a.a. and has a predicted molecular mass of 63.5 (or 66) kDa. As a result of glycosylation, the apparent molecular mass of rmCDH5 is approximately 75-85 kDa in SDS-PAGE under reducing conditions.
Purity	>90% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.