Recombinant Mouse TROP2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4675
Recombinant Mouse TROP2 Protein (His Tag)

Recombinant Mouse TROP2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4675
Catalog No.: BLPSN-4675

Product Overview

Tag His
Host Species Mouse
Accession Q8BGV3
Synonym C80403, EGP-1, GA733-1, Ly97, TROP2
Background TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.
Description A DNA sequence encoding the extracellular domain of mouse TACSTD2 (Q8BGV3?) (Met 1-Gln 270) was expressed, with a C-terminal His tag.
Source HEK293
Predicted N Terminal Gln 25
AA Sequence Met 1-Gln 270
Molecular Weight The secreted recombinant mouse TACSTD2 comprises 257 a.a. and has a calculated molecular mass of 29.4 kDa. As a result of glycosylation, the apparent molecular mass of rmTACSTD2 is approximately 45 kDa in SDS-PAGE under reducing conditions.
Purity >92% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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