Name: Recombinant Mouse TLR3 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-4548
Availability: InStock

Recombinant Mouse TLR3 Protein (His Tag)

Catalog No.: BLPSN-4548

Product Overview

Tag	His
Host Species	Mouse
Accession	NP_569054.2
Synonym	AI957183, Tlr3
Background	Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Description	A DNA sequence encoding the extracellular domain of mouse TLR3 (NP_569054.2) (Met 1-Leu 705) was expressed with a C-terminal His tag.
Source	HEK293
Predicted N Terminal	Thr 26
AA Sequence	Met 1-Leu 705
Molecular Weight	The secreted recombinant mouse TLR3 consists of 691 a.a. and has a calculated molecular mass of 78.7 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 100-110 kDa protein in SDS-PAGE under reducing conditions.
Purity	>97% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.