Recombinant Mouse Her2 / ERBB2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2404
Recombinant Mouse Her2 / ERBB2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2404
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Mouse |
Accession | P70424 |
Synonym | ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2 |
Background | Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu. ERBB2, commonly referred to as HER2, is amplified and/or overexpressed in 20-30% of invasive breast carcinomas. HER2-positive breast cancer is treated in a separate manner from other subtypes of breast cancer and commonly presents as more aggressive disease. Metastatic HER2-positive breast cancer is now commonly treated with HER2-targeted therapy. Apart from being amplified/overexpressed, ERBB2 activating mutations have been shown to have clinical importance in HER2-negative breast cancer. These mutations have shown sensitivity to the tyrosine kinase inhibitor neratinib, and highlight the importance of clinical sequencing efforts in treating breast cancer. |
Description | A DNA sequence encoding the mouse ERBB2 (P70424) extracellular domain (Met 1-Thr 653) was expressed, with a C-terminal His tag. |
Source | HEK293 |
Predicted N Terminal | Thr 23 |
AA Sequence | Met 1-Thr 653 |
Molecular Weight | The secreted recombinant mouse ERBB2 comprises 642 amino acids and has a calculated molecular mass of 71.1 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 100-110 kDa in SDS-PAGE under reducing conditions. |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Please contact us for detailed information |
Formulation | Recombinant Mouse Her2 / ERBB2 Protein (His Tag) was lyophilized from sterile PBS, pH 7.4 |
Stability | Recombinant Mouse Her2 / ERBB2 protein is stable up to 1 year at -70°C |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |