Name: Recombinant Mouse GFR alpha-2 / GDNFRB Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-2239
Availability: InStock

Recombinant Mouse GFR alpha-2 / GDNFRB Protein (His Tag)

Catalog No.: BLPSN-2239

Product Overview

Tag	His
Host Species	Mouse
Accession	NP_032141.2
Background	GFRA2 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA2 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA/GDNFRa acts as the ligand-binding component. Experiments have improved that GFRA2 genetic variants and age may play a role in Tardive dyskinesia (TD) susceptibility, but further work is required to confirm these findings.
Description	A DNA sequence encoding the mouse GFRalpha2 (NP_032141.2) (Met 1-Ser 441) without the propeptide was expressed, fused with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Ser 22
AA Sequence	Met 1-Ser 441
Molecular Weight	The secreted recombinant mouse GFRalpha2 consists of 431 a.a. and has a calculated molecular mass of 48.5 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.
Purity	>85% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.