Recombinant Mouse ESM1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1941
Recombinant Mouse ESM1 Protein (His Tag)

Recombinant Mouse ESM1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1941
Catalog No.: BLPSN-1941

Product Overview

Tag His
Host Species Mouse
Accession Q9QYY7
Synonym 0610042H23Rik, AV004503, ESM-1
Background ESM1 is a secreted protein which is produced by adipocytes. It has been noticed that ESM1 may play some role in obesity-associated vascular disease since circulating ESM-1 levels are reduced in the overweight and obese. ESM1 is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Recently, ESM1 has been described as a specific biomarker of tip cells during neoangiogenesis. Its expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF or FGF-2. In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against ESM1.
Description A DNA sequence encoding the mouse TLR2 (Q9QYY7) (Met1-Arg184) was fused with a His tag at the C-terminus.
Source Baculovirus-Insect Cells
Predicted N Terminal Ala 22
AA Sequence Met1-Arg184
Molecular Weight The recombinant mouse ESM1 consists of 173 a.a. and has a calculated molecular mass of 19.1 kDa. The recombinant protein migrates as an approximately 23 kDa band in SDS-PAGE under reducing conditions.
Purity >95% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10%gly.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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