Recombinant Mouse DPP2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1648
Recombinant Mouse DPP2 Protein (His Tag)

Recombinant Mouse DPP2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1648
Catalog No.: BLPSN-1648

Product Overview

Tag His
Host Species Mouse
Accession NP_114031.2
Synonym Dpp2, DPPII, QPP
Background DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP1, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.
Description A DNA sequence encoding the mouse DPP7 (Q9ET221) (Met1-Arg 506) was expressed, with a C-terminal His tag.
Source HEK293
Predicted N Terminal Asp 34
AA Sequence Met1-Arg 506
Molecular Weight The recombinant mouse DPP7 consists of 484 a.a. and predicts a molecular mass of 53.7 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmDPP7 is approximately 65 KDa as a result of glycosylation.
Purity >92% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Measured by its ability to cleave the fluorogenic peptide substrate, Lys-Pro-AMC(KP-AMC).The specific activity is > 20,000 pmoles/min/ug.
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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