Recombinant Mouse CLEC3A Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1305
Recombinant Mouse CLEC3A Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1305
Catalog No.: BLPSN-1305
Product Overview
| Tag | His |
| Host Species | Mouse |
| Synonym | 1110019O10Rik, Clecsf1, Gm796 |
| Background | C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Elevated CLEC3A expression may correlate with breast IDC metastatic potential and indicated a poor prognosis in breast IDC. CLEC3A knockdown inhibited BC cell growth and metastasis might be through suppressing PI3K/AKT signaling activity. That CLEC3A is a promising therapeutic target for BC in the future. Matrilysin (MMP-7) plays important roles in tumor progression. Previous studies have suggested that MMP-7 binds to tumor cell surface and promotes their metastatic potential. C-type lectin domain family 3 member A (CLEC3A) as a membrane-bound substrate of MMP-7. CLEC3A binds to heparan sulfate proteoglycans on cell surface, leading to the enhancement of cell adhesion to integrin ligands on ECM. It can be speculated that the cleavage of CLEC3A by MMP-7 weakens the stable adhesion of tumor cells to the matrix and promotes their migration in tumor microenvironments. |
| Description | A DNA sequence encoding the mouse CLEC3A (NP_001007224.1) (Met1-Pro196) was expressed with a His tag at the C-terminus. |
| Source | Baculovirus-Insect Cells |
| Predicted N Terminal | Tyr 23 |
| AA Sequence | Met1-Pro196 |
| Molecular Weight | The recombinant mouse CLEC3A consists of 185 a.a. and predicts a molecular mass of 21.3 kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 20 mM Tris, pH 8.0, 300 mM NaCl, 10 % glycerol.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
