Recombinant Mouse ALK-1 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0117NP
Recombinant Mouse ALK-1 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0117NP
Catalog No.: BL-0117NP
Product Overview
| Tag | Fc |
| Host Species | Mouse |
| Accession | Q61288 |
| Synonym | ALK-1 Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; ACVRL1; activin A receptor type II-like 1; activin A receptor |
| Background | Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair. |
| Description | Recombinant Mouse Activin Receptor-like Kinase 1 is expressed by our Mammalian expression system and the target gene encoding Asp23-Pro119 is expressed with a Fc tag at the C-terminus. |
| Source | Human Cells |
| AA Sequence | Asp23-Pro119 |
| Purity | >95% as determined by reducing SDS-PAGE. |
| Endotoxin | <0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Recombinant Mouse ALK-1 Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Reconstitution | Dissolve the lyophilized protein in distilled water. |
| Usage | For Research Use Only |
| Storage | Mouse ALK-1 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
