Recombinant Mouse Adiponectin Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0095
Recombinant Mouse Adiponectin Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0095
Catalog No.: BLPSN-0095
Product Overview
| Tag | His |
| Host Species | Mouse |
| Accession | NP_033735.3 |
| Synonym | 30kDa, Acdc, Acrp30, Ad, adipo, apM1, APN, GBP28 |
| Background | Adiponectin (ADIPOQ), or 3 kDa adipocyte complement-related protein (Acrp3) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other tissues. Adiponectin mediates its actions in the periphery mainly via two receptors, AdipoR1 and AdipoR2. Adiponectin influences gonadotropin release, normal pregnancy, and assisted reproduction outcomes. Adiponectin, a beneficial adipokine, represents a major link between obesity and reproduction. Higher levels of adiponectin are associated with improved menstrual function and better outcomes in assisted reproductive cycles. Unlike other adipocytokines produced by adipose tissue, adiponectin appears to have anti-inflammatory, anti-diabetic, and anti-atherogenic properties. Several clinical studies demonstrate the inverse relationship between plasma adiponectin levels and several inflammatory markers including C-reactive protein. Adiponectin attenuates inflammatory responses to multiple stimuli by modulating signaling pathways in a variety of cell types. The anti-inflammatory properties of adiponectin may be a major component of its beneficial effects on cardiovascular and metabolic disorders including atherosclerosis and insulin resistance. Additionally, it is important factor in chronic liver diseases and chronic kidney diseases. Some cancer cell types express adiponectin receptors. Thus Adiponectin may act on tumour cells directly by binding and activating adiponectin receptors and downstream signalling pathways. |
| Description | A DNA sequence encoding the mouse ADIPOQ (NP_033735.3) (Met 1-Asn 247) was expressed, with a C-terminal His tag. |
| Source | HEK293 |
| Predicted N Terminal | Glu 18 |
| AA Sequence | Met 1-Asn 247 |
| Molecular Weight | The secreted recombinant mouse ADIPOQ comprises 241 a.a. and has a calculated molecular mass of 26.4 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions. |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
