Recombinant Mouse 15-PGDH Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0015
Recombinant Mouse 15-PGDH Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0015
Collections: Other recombinant proteins, Recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Mouse |
Accession | Q8VCC1 |
Synonym | 15-PGDH, AV026552 |
Background | 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor inmany species and regulate uterine contractility and cervicaldilatation. Therefore, the regulation of prostaglandin outputby PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activitypatterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR), cranioosteoarthropathy (COA),and isolated congenital nail clubbing. |
Description | A DNA sequence encoding the mouse HPGD (Q8VCC1) (Met 1-Ser 269) was expressed, with a His tag at the C-terusmin. |
Source | E.coli |
Predicted N Terminal | Met 1 |
AA Sequence | Met 1-Ser 269 |
Molecular Weight | The recombinant mouse HPGD consisting of 279 a.a. and has a calculated molecular mass of 30.6 kDa. rmHPGD migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions as predicted. |
Purity | >90% as determined by SDS-PAGE |
Endotoxin | Please contact us for more information. |
Bioactivity | Measured by its ability to bind Rhesus ErbB3-His in functional Elisa. |
Formulation | Lyophilized from sterile PBS, pH 8.0, 20% glycerol. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |