Recombinant Human Zinc Finger Protein 175 (ZNF175) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-09960P

Greater than 90% as determined by SDS-PAGE.
Recombinant Human Zinc Finger Protein 175 (ZNF175) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-09960P
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Description | Recombinant Human Zinc Finger Protein 175 (ZNF175) Protein (His-SUMO) is produced by our E.coli expression system. This is a full length protein. |
Purity | Greater than 90% as determined by SDS-PAGE. |
Uniprotkb | Q9Y473 |
Target Symbol | ZNF175 |
Synonyms | OTK18; Zinc finger protein 175; Zinc finger protein OTK18; ZN175_HUMAN; ZNF175 |
Species | Homo sapiens (Human) |
Expression System | E.coli |
Tag | N-6His-SUMO |
Target Protein Sequence | MPADVNLSQKPQVLGPEKQDGSCEASVSFEDVTVDFSREEWQQLDPAQRCLYRDVMLELYSHLFAVGYHIPNPEVIFRMLKEKEPRVEEAEVSHQRCQEREFGLEIPQKEISKKASFQKDMVGEFTRDGSWCSILEELRLDADRTKKDEQNQIQPMSHSAFFNKKTLNTESNCEYKDPGKMIRTRPHLASSQKQPQKCCLFTESLKLNLEVNGQNESNDTEQLDDVVGSGQLFSHSSSDACSKNIHTGETFCKGNQCRKVCGHKQSLKQHQIHTQKKPDGCSECGGSFTQKSHLFAQQRIHSVGNLHECGKCGKAFMPQLKLSVYLTDHTGDIPCICKECGKVFIQRSELLTHQKTHTRKKPYKCHDCGKAFFQMLSLFRHQRTHSREKLYECSECGKGFSQNSTLIIHQKIHTGERQYACSECGKAFTQKSTLSLHQRIHSGQKSYVCIECGQAFIQKAHLIVHQRSHTGEKPYQCHNCGKSFISKSQLDIHHRIHTGEKPYECSDCGKTFTQKSHLNIHQKIHTGERHHVCSECGKAFNQKSILSMHQRIHTGEKPYKCSECGKAFTSKSQFKEHQRIHTGEKPYVCTECGKAFNGRSNFHKHQITHTRERPFVCYKCGKAFVQKSELITHQRTHMGEKPYECLDCGKSFSKKPQLKVHQRIHTGERPYVCSECGKAFNNRSNFNKHQTTHTRDKSYKCSYSVKGFTKQ |
Expression Range | 1-711aa |
Protein Length | Full Length |
Mol. Weight | 97.6kDa |
Research Area | Epigenetics And Nuclear Signaling |
Form | Liquid or Lyophilized powder |
Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution | Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Target Details
Target Function | Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity. |
Subcellular Location | Cytoplasm. Nucleus. |
Protein Families | Krueppel C2H2-type zinc-finger protein family |
Database References | |
Tissue Specificity | Ubiquitous. |
Gene Functions References
- Transcriptional suppressor OTK18 plays a role in macrophage control of viral replication during advanced HIV-1 infection. PMID: 14688346
- OTK18/zinc finger protein 175 expression in brain mononuclear phagocytes is a signature for advanced HIV-1 encephalitis. PMID: 15081264
- Plasma OTK18 levels are positively correlated to CD8 T-cell counts, independent of HIV-1 status. PMID: 18773297
- These results suggest a role for OTK18 in innate immunity. PMID: 18776638
- These data suggest that calpain and proteasome are involved in OTK18 endoproteolysis and degradation PMID: 19034669
- HIV-1 induces OTK18 expression through a YIN-YANG-1 mediated manner in human macrophages PMID: 19034670
- OTK18 may play a role in neurotrophin production and consequently support neuronal survival. PMID: 19247725