Recombinant Human VAPB Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4759
Recombinant Human VAPB Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4759
Catalog No.: BLPSN-4759
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | O95292 |
| Synonym | ALS8, VAMP-B, VAP-B |
| Background | Vesicle-associated membrane protein-associated protein B / C, also known as VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C and VAPB, is a single-pass type IV membrane protein which belongs to theVAMP-associated protein ( VAP ) family. VAPB contains oneMSP domain. VAPB may play a role in vesicle trafficking. VAPB forms a heterodimer with VAPA. VAPB interacts with VAMP1 and VAMP2. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 ( ALS8 ) which is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Defects in VAPB are also a cause of spinal muscular atrophy autosomal dominant Finkel type ( SMAF ) which is characterized by proximal muscle weakness that begins in the lower limbs and then progresses to upper limbs. |
| Description | A DNA sequence encoding the human VAPB (O95292-1) N-terminal fragment (Met 1-Pro 132) was fused with a His tag at the C-terminus. |
| Source | E.coli |
| Predicted N Terminal | Met |
| AA Sequence | Met 1-Pro 132 |
| Molecular Weight | The recombinant human VAPB consisting of 142 a.a. and has a calculated molecular mass of 16.3 kDa. It migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions. |
| Purity | >97% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Measured by its ability to bind recombinant human EphB2 in a functional ELISA. |
| Formulation | Lyophilized from sterile PBS, pH 8.0. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
