Recombinant Human VAPB Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4759
Recombinant Human VAPB Protein (His Tag)

Recombinant Human VAPB Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4759
Catalog No.: BLPSN-4759

Product Overview

Tag His
Host Species Human
Accession O95292
Synonym ALS8, VAMP-B, VAP-B
Background Vesicle-associated membrane protein-associated protein B / C, also known as VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C and VAPB, is a single-pass type IV membrane protein which belongs to theVAMP-associated protein ( VAP ) family. VAPB contains oneMSP domain. VAPB may play a role in vesicle trafficking. VAPB forms a heterodimer with VAPA. VAPB interacts with VAMP1 and VAMP2. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 ( ALS8 ) which is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Defects in VAPB are also a cause of spinal muscular atrophy autosomal dominant Finkel type ( SMAF ) which is characterized by proximal muscle weakness that begins in the lower limbs and then progresses to upper limbs.
Description A DNA sequence encoding the human VAPB (O95292-1) N-terminal fragment (Met 1-Pro 132) was fused with a His tag at the C-terminus.
Source E.coli
Predicted N Terminal Met
AA Sequence Met 1-Pro 132
Molecular Weight The recombinant human VAPB consisting of 142 a.a. and has a calculated molecular mass of 16.3 kDa. It migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions.
Purity >97% as determined by SDS-PAGE
Endotoxin Please contact us for more information.
Bioactivity Measured by its ability to bind recombinant human EphB2 in a functional ELISA.
Formulation Lyophilized from sterile PBS, pH 8.0.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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