Recombinant Human UCHL1 Protein

Beta LifeScience SKU/CAT #: BL-0169SG
Recombinant Human UCHL1 Protein

Recombinant Human UCHL1 Protein

Beta LifeScience SKU/CAT #: BL-0169SG
Catalog No.: BL-0169SG

Product Overview

Tag His
Host Species Human
Accession NM_004181
Synonym PGP 9.5, UCH-L1, NDGOA, PGP95, SPG79, PARK5
Background UCHL1 (ubiquitin carboxyl-terminal esterase L1) is a member of the peptidase C12 family and is a thiol protease that hydrolyzes the C-terminal glycine of ubiquityl esters and amides. It is expressed in the brain and neuroendocrine system and is essential for cytoplasmic protein degradation via recycling free ubiquitin. Mutations in UCHL1 are associated with Parkinson-€™s Disease (PD) due to its ligase and hydrolase activity, both of which are crucial for neuronal health (1). Dysfunction of the enzyme is also associated with Alzheimer-€™s disease as UCHL1 was found to interact with amyloid beta precursor protein and regulates the production of amyloid beta protein (2).
Description Recombinant human UCHL1 was produced in E. coli system, fused with a His tag at N-terminus.
Source E.coli
Molecular Weight 25 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human UCHL1 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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