Recombinant Human UBASH3A Protein (aa 354-623, His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4709
Recombinant Human UBASH3A Protein (aa 354-623, His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4709
Catalog No.: BLPSN-4709
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | AAH69511.1 |
| Synonym | CLIP4, STS-2, TULA, TULA-1 |
| Background | UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of UBASH3A gene results in multiple transcript variants. It interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. UBASH3A promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. UBASH3A also exhibits negligigle protein tyrosine phosphatase activity at neutral pH. It may act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. It may also inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. |
| Description | A DNA sequence encoding the mature form of human UBASH3A (AAH69511.1) (Ala354-Asn623) was expressed with a His tag at the N-terminus. |
| Source | E.coli |
| Predicted N Terminal | His |
| AA Sequence | Ala354-Asn623 |
| Molecular Weight | The recombinant human UBASH3A consists of 286 a.a. and predicts a molecular mass of 32.2 KDa. It migrates as an approximately 30 KDa band in SDS-PAGE under reducing conditions. |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
