Recombinant Human TRXR1 Protein (aa 161-647, His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4685
Recombinant Human TRXR1 Protein (aa 161-647, His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4685
Catalog No.: BLPSN-4685
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | Q16881 |
| Synonym | GRIM-12, TR, TR1, TRXR1, TXNR |
| Background | Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction. |
| Description | A DNA sequence encoding the human TXNRD1 isoform 1 (Q16881-1) (Tyr 161-Cys 647) was expressed, with a His tag at the N-terminus. |
| Source | E.coli |
| Predicted N Terminal | Met |
| AA Sequence | Tyr 161-Cys 647 |
| Molecular Weight | The recombinant human TXNRD1 consisting of 498 a.a. and has a calculated molecular mass of 55 kDa. It migrates as an 60 kDa band in SDS-PAGE under reducing conditions as predicted. |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
