Name: Recombinant Human TRP1 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-4683
Availability: InStock

Recombinant Human TRP1 Protein (His Tag)

Catalog No.: BLPSN-4683

Product Overview

Tag	His
Host Species	Human
Accession	P17643
Synonym	b-PROTEIN, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP
Background	Tyrosinase-related protein 1, also known as TYRP1 or TRP1, is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.
Description	A DNA sequence encoding the human TYRP1 (P17643) extracellular domain (Met 1- Arg 471) was fused with a His tag at the C-terminus.
Source	Baculovirus-Insect Cells
Predicted N Terminal	Gln 25
AA Sequence	Met 1- Arg 471
Molecular Weight	The secreted recombinant human TYRP1 comprises 458 a.a. and has a predicted molecular mass of 52 kDa. The apparent molecular mass of rh TRP1 is approximately 55 kDa in SDS-PAGE under reducing conditions.
Purity	>96% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.