Recombinant Human TRKA (G667S) Protein

Beta LifeScience SKU/CAT #: BL-0056SG
Recombinant Human TRKA (G667S) Protein

Recombinant Human TRKA (G667S) Protein

Beta LifeScience SKU/CAT #: BL-0056SG
Catalog No.: BL-0056SG

Product Overview

Tag GST
Host Species Human
Accession NM_002529
Synonym NTRK1; MTC; TRK; TRK1; p140-TrkA; DKFZp781I14186
Background TRKA is a member of the trk proto-oncogene family and encodes a 140kDa, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation (1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease (2).
Description Recombinant human TRKA (G667S) (440-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 440a.a.-end
Molecular Weight 66 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human TRKA (G667S) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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