Recombinant Human TRKA (G667S) Protein
Beta LifeScience
SKU/CAT #: BL-0056SG
Recombinant Human TRKA (G667S) Protein
Beta LifeScience
SKU/CAT #: BL-0056SG
Catalog No.: BL-0056SG
Product Overview
| Tag | GST |
| Host Species | Human |
| Accession | NM_002529 |
| Synonym | NTRK1; MTC; TRK; TRK1; p140-TrkA; DKFZp781I14186 |
| Background | TRKA is a member of the trk proto-oncogene family and encodes a 140kDa, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation (1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease (2). |
| Description | Recombinant human TRKA (G667S) (440-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. |
| Source | Sf9 insect cells |
| AA Sequence | 440a.a.-end |
| Molecular Weight | 66 kDa |
| Purity | For specific purity information on a given lot, see related COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Active |
| Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| Stability | The recombinant protein is stable for up to 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Recombinant Human TRKA (G667S) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
