Recombinant Human TRIB2 Protein (His & GST Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4647
Recombinant Human TRIB2 Protein (His & GST Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4647
Catalog No.: BLPSN-4647
Product Overview
| Tag | His&GST |
| Host Species | Human |
| Accession | NP_006204.1 |
| Synonym | C5FW, FLJ57420, GS3955, TRB2, TRIB2 |
| Background | Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate activation of a number of intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression. Tribbles controls the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed. This mechanism for coordinating cell division and cell-shape changes may have helped Drosophila to evolve its mode of rapid early development. Trib2 was identified as a downregulated transcript in leukemic cells undergoing growth arrest. Trib2-transduced bone marrow cells exhibited a growth advantage and readily established factor-dependent cell lines. Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML). |
| Description | A DNA sequence encoding the human TRIB2 (NP_067675.1) (Met 1-Asn 343) was fused with the GST tag at the N-terminus and a His tag at the C-terminus. |
| Source | Baculovirus-Insect Cells |
| Predicted N Terminal | Met |
| AA Sequence | Met 1-Asn 343 |
| Molecular Weight | The recombinant human TRIB2/GST chimera consists of 578 a.a. and predicts a molecular mass of 66 kDa. |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Formulation | Supplied as sterile 50mM Tris, 100mM NaCl, 1mM GSH, 0.5mM PMSF, pH 8.0. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
