Recombinant Human TREML2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4644
Recombinant Human TREML2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4644
Collections: Other recombinant proteins, Recombinant proteins
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_079083.2 |
| Synonym | C6orf76, dJ238O23.1, FLJ13693, MGC149715, MGC149716, TLT-2, TLT2, UNQ6268/PRO20473 |
| Background | Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein which contains oneIg-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TREML2 was expressed on CD8(+) T cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8(+) T cells. Transduction of TREML2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There maybe a direct interaction between B7-H3 and TREML2 that preferentially enhances CD8(+) T cell activation. |
| Description | A DNA sequence encoding the human TREML2 (NP_079083.2) extracellular domain (Met 1-Ser 268) was fused with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Gly 19 |
| AA Sequence | Met 1-Ser 268 |
| Molecular Weight | The recombinant human TREML2 consists of 261 a.a. and has a predicted molecular mass of 28.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh TREML2 is approximately 55-60 kDa due to glycosylation. |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
