Recombinant Human TREML2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4644
Recombinant Human TREML2 Protein (His Tag)

Recombinant Human TREML2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4644
Catalog No.: BLPSN-4644

Product Overview

Tag His
Host Species Human
Accession NP_079083.2
Synonym C6orf76, dJ238O23.1, FLJ13693, MGC149715, MGC149716, TLT-2, TLT2, UNQ6268/PRO20473
Background Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein which contains oneIg-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TREML2 was expressed on CD8(+) T cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8(+) T cells. Transduction of TREML2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There maybe a direct interaction between B7-H3 and TREML2 that preferentially enhances CD8(+) T cell activation.
Description A DNA sequence encoding the human TREML2 (NP_079083.2) extracellular domain (Met 1-Ser 268) was fused with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Gly 19
AA Sequence Met 1-Ser 268
Molecular Weight The recombinant human TREML2 consists of 261 a.a. and has a predicted molecular mass of 28.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh TREML2 is approximately 55-60 kDa due to glycosylation.
Purity >95% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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