Recombinant Human TMP21 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4572
Recombinant Human TMP21 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4572
Catalog No.: BLPSN-4572
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | NP_006818.3 |
| Synonym | p23, P24(DELTA), S31I125, S31III125, Tmp-21-I, TMP21 |
| Background | TMED1 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED1 attenuated TGF-beta-mediated signaling. A 2-amino acid-long region from Thr(91) to Glu(11) within the extracellular region of TMED1 was found to be crucial for TMED1 interaction with both ALK5 and TbetaRII. Synthetic peptides corresponding to this region inhibit both TGF-beta-induced Smad2 phosphorylation and Smad-dependent transcriptional reporter activity. In a xenograft cancer model, where previously TGF-beta was shown to elicit tumor-promoting effects, gain-of-function and loss-of-function studies for TMED1 revealed a decrease and increase in the tumor size, respectively. That TMED1 expression levels are the key determinant for efficiency of TGF-beta receptor complex formation and signaling. |
| Description | A DNA sequence encoding the human TMED10 (NP_006818.3) (Met1-Arg185) was expressed with the Fc region of mouse IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Ile 32 |
| AA Sequence | Met1-Arg185 |
| Molecular Weight | The recombinant human TMED10 consists 388 a.a. and predicts a molecular mass of 44 kDa. |
| Purity | >(61.4 + 28.2)% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
