Recombinant Human TMEM27 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-4567
Recombinant Human TMEM27 Protein (Fc Tag)

Recombinant Human TMEM27 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-4567
Catalog No.: BLPSN-4567

Product Overview

Tag Fc
Host Species Human
Accession Q9HBJ8
Synonym NX-17, NX17
Background TMEM27 is a membrane protein. It has been proposed as a beta cell mass biomarker since it is cleaved and shed by pancreatic beta cells. Overexpression of TMEM27 leads to increased thymidine incorporation, whereas silencing of Tmem27 using RNAi results in a reduction of cell replication. Furthermore, transgenic mice with increased expression of Tmem27 in pancreatic beta cells exhibit increased beta cell mass. TMEM27 is also important for trafficking amino acid transporters to the apical brush border of proximal tubules.
Description A DNA sequence encoding the human TMEM27 (Q9HBJ8) (Met1-Pro141) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source HEK293
Predicted N Terminal Glu 15
AA Sequence Met1-Pro141
Molecular Weight The recombinant human TMEM27 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 368 a.a. and has a predicted molecular mass of 41.4 kDa. The apparent molecular mass of the protein is approximately 53-57 kDa in SDS-PAGE under reducing conditions.
Purity >95% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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