Recombinant Human SQSTM1 Protein

Beta LifeScience SKU/CAT #: BL-4237PS
Recombinant Human SQSTM1 Protein

Recombinant Human SQSTM1 Protein

Beta LifeScience SKU/CAT #: BL-4237PS
Catalog No.: BL-4237PS

Product Overview

Tag N/A
Host Species Human
Synonym A170, OSIL, p60, p62, p62B, PDB3, ZIP3, EBIAP, ORCA, OSIL, SQSTM1.
Background SQSTM1 is an adapter protein which binds ubiquitin and mediates the activation of NFKB1 by TNF-a, NGF and IL-1. SQSTM1 is involved in titin/TTN downstream signaling in muscle cells. SQSTM1 controls signaling cascades through ubiquitination. SQSTM1 participates in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Mutations in UBA domain of the SQSTM1 protein cause Paget's disease because the UBA is essential for aggregate sequestration and cell survival.
Description SQSTM1 Human Recombinant expressed in E.Coli is a single, non-glycosylated, polypeptide chain containing 264a.a. (1-356 a.a.) and having a molecular weight of 39.7 kDa. SQSTM1 protein is fused to an 8a.a. His-Tag at C-terminus and purified by standard chromatography.
Source E.coli
AA Sequence MAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EARPGPTAES ASGPSEDPSV NFLKNVGESV AAALSPLGIE VDIDVEHGGK RSRLTPVSPE SSSTEEKSSS QPSSCCSDPS KPGGNVEGAT QSLAEQMRKI ALESEGRPEE QMESDNCSGG DDDWTHLSSK EVDPSTGELQ SLQMPESEGP SSLDPSQEGP TGLKEAALYP HLPPEADPRL IESLSQMLSM GFSDEGGWLT RLLQTKNYDI GAALDTIQYS KHPPPLLEHH HHHH.
Purity >90% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation SQSTM1 Human solution containing 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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