Recombinant Human SOD2 Protein

Beta LifeScience SKU/CAT #: BL-4705PS
Recombinant Human SOD2 Protein

Recombinant Human SOD2 Protein

Beta LifeScience SKU/CAT #: BL-4705PS
Catalog No.: BL-4705PS

Product Overview

Tag N/A
Host Species Human
Synonym MNSOD, MVCD6, IPOB, Mn superoxide dismutase, EC=1.15.1.1.
Background SOD2 is part of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. SOD2 destroys radicals which are usually expressed within the cells and which are toxic to biological systems.
Description SOD2 Human Recombinant expressed in E.Coli is a single, non-glycosylated,polypeptide chain containing 219a.a.(25-222 a.a.) and having a molecular weight of 24.4kDa. SOD2 protein is fused to a 20a.a. His-Tag at N-terminus and purified by standard chromatography.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MKHSLPDLPY DYGALEPHIN AQIMQLHHSK HHAAYVNNLN VTEEKYQEAL AKGDVTAQIA LQPALKFNGG GHINHSIFWT NLSPNGGGEP KGELLEAIKR DFGSFDKFKE KLTAASVGVQ GSGWGWLGFN KERGHLQIAA CPNQDPLQGT TGLIPLLGID VWEHAYYLQY KNVRPDYLKA IWNVINWENV TERYMACKK.
Purity >95% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Bioactivity Specific activity is > 1,200 units/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.8 at 25C in a 1.5 ml reaction volume.
Formulation SOD2 Human solution containing 20mM Tris-HCl pH-8 & 20% glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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