Recombinant Human SIK3 Protein
Beta LifeScience
SKU/CAT #: BL-0275SG
Recombinant Human SIK3 Protein
Beta LifeScience
SKU/CAT #: BL-0275SG
Catalog No.: BL-0275SG
Product Overview
| Tag | GST |
| Host Species | Human |
| Accession | BC128510 |
| Synonym | QSK; SIK-3; L19; FLJ12240; KIAA0999 |
| Background | SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm (1). Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer (2). There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer (3). SIK3 is a novel tumor-associated antigen (TAA). |
| Description | Recombinant human SIK3 (1-307) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. |
| Source | Sf9 insect cells |
| AA Sequence | 1-307a.a. |
| Molecular Weight | ~62 kDa |
| Purity | For specific purity information on a given lot, see related COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Active |
| Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| Stability | The recombinant protein is stable for up to 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Recombinant Human SIK3 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
