Recombinant Human Siglec-2 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0218NP
Recombinant Human Siglec-2 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0218NP
Catalog No.: BL-0218NP
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | P20273 |
| Synonym | Siglec-2 B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22 molecule; CD22; sialic acid binding Ig-like lectin 2; Siglec-2; SIGLEC2FLJ22814; T-cell surface antigen Leu-14 |
| Background | Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or B-lymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec-2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec-2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis. |
| Description | Recombinant Human B-cell Receptor CD22 is expressed by our Mammalian expression system and the target gene encoding Asp20-Arg687 is expressed with a Fc tag at the C-terminus. |
| Source | Human Cells |
| AA Sequence | Asp20-Arg687 |
| Purity | >95% as determined by reducing SDS-PAGE. |
| Endotoxin | <0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Recombinant Human Siglec-2 Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 . |
| Reconstitution | Dissolve the lyophilized protein in distilled water. |
| Usage | For Research Use Only |
| Storage | Human Siglec-2 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
