Recombinant Human Serine/Threonine-Protein Phosphatase 2A 55 Kda Regulatory Subunit B Gamma Isoform (PPP2R2C) Protein (His&Myc)

Name: Recombinant Human Serine/Threonine-Protein Phosphatase 2A 55 Kda Regulatory Subunit B Gamma Isoform (PPP2R2C) Protein (His&Myc)
Brand: Beta LifeScience
SKU: BLC-03689P
Availability: InStock

Greater than 85% as determined by SDS-PAGE.

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Product Overview

Description	Recombinant Human Serine/Threonine-Protein Phosphatase 2A 55 Kda Regulatory Subunit B Gamma Isoform (PPP2R2C) Protein (His&Myc) is produced by our E.coli expression system. This is a full length protein.
Purity	Greater than 85% as determined by SDS-PAGE.
Uniprotkb	Q9Y2T4
Target Symbol	PPP2R2C
Synonyms	2ABG_HUMAN; B55 gamma; Gamma isoform of regulatory subunit B55 protein phosphatase 2; IMYPNO 1; IMYPNO; IMYPNO1; MGC33570; OTTHUMP00000115505; Phosphoprotein phosphatase 2A BR gamma regulatory chain; PP2A subunit B B gamma isoform; PP2A subunit B B55 gamma isoform; PP2A subunit B isoform B55-gamma; PP2A subunit B isoform gamma; PP2A subunit B isoform PR55-gamma; PP2A subunit B isoform R2-gamma; PP2A subunit B PR55 gamma isoform; PP2A subunit B R2 gamma isoform; PPP2R2C; PPP2R2C protein; PR 52; PR 55G; PR52; PR55G; Protein phosphatase 2 (formerly 2A) regulatory subunit B gamma isoform; Protein phosphatase 2 regulatory subunit B gamma; Protein phosphatase 2 regulatory subunit B gamma isoform; Protein phosphatase 2A1 B gamma subunit; Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Species	Homo sapiens (Human)
Expression System	E.coli
Tag	N-10His&C-Myc
Target Protein Sequence	MGEDTDTRKINHSFLRDHSYVTEADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYENDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH
Expression Range	1-447aa
Protein Length	Full Length
Mol. Weight	58.5 kDa
Research Area	Signal Transduction
Form	Liquid or Lyophilized powder
Buffer	Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution	Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%.
Storage	1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target Function	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Protein Families	Phosphatase 2A regulatory subunit B family
Database References	HGNC: 9306 OMIM: 605997 KEGG: hsa:5522 STRING: 9606.ENSP00000335083 UniGene: PMID: 28805158 miR-572 promotes the proliferation and invasion of nasopharyngeal carcinoma by directly down-regulating PPP2R2C PMID: 28525724 miR-1301 promoted prostate cancer proliferation by inhibiting PPP2R2C. PMID: 27261573 These findings provide insights into mechanisms by which prostate cancers resist AR-pathway suppression and support inhibiting PPP2R2C complexes. PMID: 23493267 PPP2R2C is a potential tumor suppressor gene in human brain cancers. PMID: 24126060 evidence suggests that allelic variation in PPP2R2C may be associated with a variety of personality traits and ADHD per se. PMID: 22664926 encoding a subunit of proteinphosphatase 2A with a unique expression pattern in brain and a role in synaptic plasticity PMID: 20601260 specific PP2A complexes involved in human cell transformation PMID: 14998489 novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma PMID: 18069897

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.