Recombinant Human RSPO1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BL-0319NP
Recombinant Human RSPO1 Protein (His Tag)

Recombinant Human RSPO1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BL-0319NP
Catalog No.: BL-0319NP

Product Overview

Tag His
Host Species Human
Accession Q2MKA7
Synonym RSPO1 RSPO1; R-spondin1; RP11-566C13.1; CRISTIN3; FLJ40906; RSPO Rspo1; R-spondin; Rspondin; RP23-325M14.2; Roof plate-specific spondin-1
Background RSPO1 is a secreted protein,containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize beta catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/beta catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.
Description Recombinant Human R-spondin-1 is expressed by our Mammalian expression system and the target gene encoding Arg31-Ala263 is expressed with a His tag at the C-terminus.
Source Human Cells
AA Sequence Arg31-Ala263
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Bioactivity Measured by its ability to bind Mouse CD36 in functional ELISA. The ED50 for this effect is less than 100 ng/ml.
Formulation Recombinant Human RSPO1 Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human RSPO1 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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