Recombinant Human Ribonuclease Inhibitor/RAI Protein

Beta LifeScience SKU/CAT #: BLA-7802P

Recombinant Human Ribonuclease Inhibitor/RAI Protein

Beta LifeScience SKU/CAT #: BLA-7802P
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.

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Product Overview

Host Species Human
Accession P13489
Synonym AW546468 C80305 MGC18200 MGC4569 MGC54054 OTTHUMP00000147628 OTTHUMP00000229864 OTTHUMP00000229865 OTTHUMP00000229866 OTTHUMP00000229870 OTTHUMP00000229871 OTTHUMP00000229872 Placental ribonuclease inhibitor Placental RNase inhibitor PRI RAI RI Ribonuclease inhibitor Ribonuclease/angiogenin inhibitor Ribonuclease/angiogenin inhibitor 1 RINI_HUMAN RNase inhibitor RNH RNH 1 RNH1 Rnh1 ribonuclease/angiogenin inhibitor 1
Description Recombinant Human Ribonuclease Inhibitor/RAI Protein was expressed in Wheat germ. It is a Full length protein
Source Wheat germ
Molecular Weight 76 kDa including tags
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Liquid Solution
Stability The recombinant protein samples are stable for up to 12 months at -80°C
Reconstitution See related COA
Unit Definition For Research Use Only
Storage Buffer Shipped on dry ice. Upon delivery aliquot and store at -80°C. Avoid freeze / thaw cycle.

Target Details

Target Function Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
Subcellular Location Cytoplasm.
Database References

Gene Functions References

  1. Results show that a low expression of RNH1 in metastasis of bladder cancer and suggest that it might regulate the function of ILK through mutual binding. PMID: 27576342
  2. a novel mechanism of ANG in regulating PI3K/AKT/mTOR signaling pathway via RI, is reported. PMID: 25193113
  3. RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria. PMID: 24107847
  4. angiogenin and ILK signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth PMID: 24769129
  5. RI could play a novel role in inhibiting metastasis of bladder cancer through regulating EMT and ILK signaling pathways. PMID: 24768914
  6. RNH1 as a regulator of HDACi resistance in gastric cancer PMID: 23584480
  7. RI might play a novel role in the development of bladder cancer through regulating EMT and the ILK signaling pathway. PMID: 23703635
  8. the anti-tumor effect of RNH1 is also involved in suppressing growth and metastasis PMID: 21125316
  9. RNH1 (as a recombinant fusion protein) is localized to mitochondria, nuclei, and cytosol in HeLa and HCT cells; RNH1 appears to bind to various mitochondrial proteins. PMID: 21276451
  10. Human ribonuclease inhibitor gene has antiangiogenic and antitumor effects when expressed in hematopoietic cells in mouse melanoma models. PMID: 15592448
  11. The conformational and oxidative stabilities of both RIs increase upon complex formation with ribonucleases. Thus, RI has evolved to maintain its inhibition of invading ribonucleases, even when confronted with extreme environmental stress. PMID: 17956129
  12. This the first measurement of the inhibition of the ribonucleolytic activity of onconase by ribonuclease inhibitor protein. PMID: 18930025


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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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