Recombinant Human Ribonuclease Inhibitor/RAI Protein
Beta LifeScience
SKU/CAT #: BLA-7802P
Recombinant Human Ribonuclease Inhibitor/RAI Protein
Beta LifeScience
SKU/CAT #: BLA-7802P
Collections: Other recombinant proteins, Recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Host Species | Human |
Accession | P13489 |
Synonym | AW546468 C80305 MGC18200 MGC4569 MGC54054 OTTHUMP00000147628 OTTHUMP00000229864 OTTHUMP00000229865 OTTHUMP00000229866 OTTHUMP00000229870 OTTHUMP00000229871 OTTHUMP00000229872 Placental ribonuclease inhibitor Placental RNase inhibitor PRI RAI RI Ribonuclease inhibitor Ribonuclease/angiogenin inhibitor Ribonuclease/angiogenin inhibitor 1 RINI_HUMAN RNase inhibitor RNH RNH 1 RNH1 Rnh1 ribonuclease/angiogenin inhibitor 1 |
Description | Recombinant Human Ribonuclease Inhibitor/RAI Protein was expressed in Wheat germ. It is a Full length protein |
Source | Wheat germ |
AA Sequence | MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISS ALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPG LLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISN NRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQAL EKDKPSLRVIS |
Molecular Weight | 76 kDa including tags |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Liquid Solution |
Stability | The recombinant protein samples are stable for up to 12 months at -80°C |
Reconstitution | See related COA |
Unit Definition | For Research Use Only |
Storage Buffer | Shipped on dry ice. Upon delivery aliquot and store at -80°C. Avoid freeze / thaw cycle. |
Target Details
Target Function | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. |
Subcellular Location | Cytoplasm. |
Database References |
Gene Functions References
- Results show that a low expression of RNH1 in metastasis of bladder cancer and suggest that it might regulate the function of ILK through mutual binding. PMID: 27576342
- a novel mechanism of ANG in regulating PI3K/AKT/mTOR signaling pathway via RI, is reported. PMID: 25193113
- RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria. PMID: 24107847
- angiogenin and ILK signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth PMID: 24769129
- RI could play a novel role in inhibiting metastasis of bladder cancer through regulating EMT and ILK signaling pathways. PMID: 24768914
- RNH1 as a regulator of HDACi resistance in gastric cancer PMID: 23584480
- RI might play a novel role in the development of bladder cancer through regulating EMT and the ILK signaling pathway. PMID: 23703635
- the anti-tumor effect of RNH1 is also involved in suppressing growth and metastasis PMID: 21125316
- RNH1 (as a recombinant fusion protein) is localized to mitochondria, nuclei, and cytosol in HeLa and HCT cells; RNH1 appears to bind to various mitochondrial proteins. PMID: 21276451
- Human ribonuclease inhibitor gene has antiangiogenic and antitumor effects when expressed in hematopoietic cells in mouse melanoma models. PMID: 15592448
- The conformational and oxidative stabilities of both RIs increase upon complex formation with ribonucleases. Thus, RI has evolved to maintain its inhibition of invading ribonucleases, even when confronted with extreme environmental stress. PMID: 17956129
- This the first measurement of the inhibition of the ribonucleolytic activity of onconase by ribonuclease inhibitor protein. PMID: 18930025