Recombinant Human PTPN12 (PTP-PEST) Protein
Beta LifeScience
SKU/CAT #: BL-0176SG
Recombinant Human PTPN12 (PTP-PEST) Protein
Beta LifeScience
SKU/CAT #: BL-0176SG
Catalog No.: BL-0176SG
Product Overview
| Tag | GST |
| Host Species | Human |
| Accession | NM_002835 |
| Synonym | PTP-PEST, PTPG1, tcag7.1075 |
| Background | Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes (1). Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events (2). |
| Description | Recombinant human PTPN12 (1-355) was produced in E. coli system using a N-terminual GST tag. This protein is purified with our unique purification methods. |
| Source | E.coli |
| AA Sequence | 1-355 |
| Molecular Weight | ~66kDa |
| Purity | For specific purity information on a given lot, see related COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Active |
| Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| Stability | The recombinant protein is stable for up to 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Recombinant Human PTPN12 (PTP-PEST) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
