Recombinant Human PTPN12 (PTP-PEST) Protein

Beta LifeScience SKU/CAT #: BL-0176SG
Recombinant Human PTPN12 (PTP-PEST) Protein

Recombinant Human PTPN12 (PTP-PEST) Protein

Beta LifeScience SKU/CAT #: BL-0176SG
Catalog No.: BL-0176SG

Product Overview

Tag GST
Host Species Human
Accession NM_002835
Synonym PTP-PEST, PTPG1, tcag7.1075
Background Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes (1). Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events (2).
Description Recombinant human PTPN12 (1-355) was produced in E. coli system using a N-terminual GST tag. This protein is purified with our unique purification methods.
Source E.coli
AA Sequence 1-355
Molecular Weight ~66kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human PTPN12 (PTP-PEST) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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