Recombinant Human Prostaglandin-H2 D-Isomerase (PTGDS) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-03157P

Greater than 90% as determined by SDS-PAGE.
Recombinant Human Prostaglandin-H2 D-Isomerase (PTGDS) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-03157P
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Description | Recombinant Human Prostaglandin-H2 D-Isomerase (PTGDS) Protein (His-SUMO) is produced by our E.coli expression system. This is a full length protein. |
Purity | Greater than 90% as determined by SDS-PAGE. |
Uniprotkb | P41222 |
Target Symbol | PTGDS |
Synonyms | Beta trace protein; Beta-trace protein; Cerebrin 28; Cerebrin-28; glutathione independent PGD synthase; Glutathione independent PGD synthetase; Glutathione-independent PGD synthase; L PGDS; Lipocalin type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; LPGDS; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; prostaglandin D synthase; prostaglandin D2 synthase (21 kDa; brain); prostaglandin D2 synthase (brain); prostaglandin D2 synthase 21kDa (brain); Prostaglandin D2 synthase; prostaglandin H2 D isomerase; Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; PTGDS; PTGDS_HUMAN; RP23-47P18.11-006 |
Species | Homo sapiens (Human) |
Expression System | E.coli |
Tag | N-6His-SUMO |
Target Protein Sequence | APEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ |
Expression Range | 23-190aa |
Protein Length | Full Length of Mature Protein |
Mol. Weight | 34.7kDa |
Research Area | Metabolism |
Form | Liquid or Lyophilized powder |
Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution | Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Target Details
Target Function | Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR. |
Subcellular Location | Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted. |
Protein Families | Calycin superfamily, Lipocalin family |
Database References | HGNC: 9592 OMIM: 176803 KEGG: hsa:5730 STRING: 9606.ENSP00000360687 UniGene: PMID: 29621631 |