Recombinant Human PLK4 Protein

Beta LifeScience SKU/CAT #: BL-0341SG
Recombinant Human PLK4 Protein

Recombinant Human PLK4 Protein

Beta LifeScience SKU/CAT #: BL-0341SG
Catalog No.: BL-0341SG

Product Overview

Tag GST
Host Species Human
Accession NM_014264
Synonym SAK, STK18
Background PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells (1).The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development (2).
Description Recombinant human PLK4 (1-836) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 1-836
Molecular Weight ~140 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human PLK4 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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