Recombinant Human PIP5K3 (PIKFYVE) Protein

Beta LifeScience SKU/CAT #: BL-0295SG
Recombinant Human PIP5K3 (PIKFYVE) Protein

Recombinant Human PIP5K3 (PIKFYVE) Protein

Beta LifeScience SKU/CAT #: BL-0295SG
Catalog No.: BL-0295SG

Product Overview

Tag GST
Host Species Human
Accession NM_015040
Synonym PIKFYVE; CFD; FAB1; PIP5K; FLJ37746; KIAA0981; MGC40423
Background PIP5K3 (also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) encodes an enzyme that phosphorylates the D-5 position in PtdIns and phospha-tidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns (3,5)biphosphate. PIP5K3 belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol but also have protein kinase activity (1). PIP5K3 regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. The inhibition of PIP5K3 renders the late endosome /lysosome compartment refractory to fusion with autop-hagosomes and multivesicular bodies (2).
Description Recombinant human PIP5K3 (1400-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 1400a.a.-end
Molecular Weight 110 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human PIP5K3 (PIKFYVE) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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