Recombinant Human PDE2A Protein
Beta LifeScience
SKU/CAT #: BL-1013SG
Recombinant Human PDE2A Protein
Beta LifeScience
SKU/CAT #: BL-1013SG
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | GST |
Host Species | Human |
Accession | NM_002599 |
Synonym | PDE2A1; PED2A4 |
Background | PDE2A is a member of the cyclic nucleotide phosphodiesterase family. PDE2A is a cGMP-specific phosphodiesterase and hydrolyzes cGMP to 5'-GMP. TNFalpha stimulation of cells leads to an increase in PDE2A expression in a p38 mitogen-activated protein kinase (MAPK)-dependent manner (1). TNFalpha-mediated up-regulation of PDE2A may destabilize endothelial barrier function in sepsis. In addition, selective PDE2A up-regulation sensitizesendothelial cells toward the permeability-increasing agent thrombin (2). Furthermore, PDE2A inhibition is effective in preventing thrombin-induced lung edema. |
Description | Recombinant full-length human PDE2A was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. This protein is purified with our unique purification methods. |
Source | Sf9 insect cells |
AA Sequence | Full Length |
Molecular Weight | ~130 kDa |
Purity | For specific purity information on a given lot, see related COA. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Active |
Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
Stability | The recombinant protein is stable for up to 12 months at -70°C |
Usage | For Research Use Only |
Storage | Recombinant Human PDE2A Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |