Recombinant Human PARP4 Protein

Beta LifeScience SKU/CAT #: BLA-6684P

Recombinant Human PARP4 Protein

Beta LifeScience SKU/CAT #: BLA-6684P
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.

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Product Overview

Host Species Human
Accession Q9UKK3
Synonym 193kDa vault protein ADP ribosyltransferase (NAD+ poly (ADP ribose) polymerase) like 1 ADP ribosyltransferase like 1 ADP-ribosyltransferase diphtheria toxin-like 4 ADPRT L1 ADPRTL 1 ADPRTL1 ARTD4 H5 proline rich I alpha I related KIAA0177 Minor vault p193 protein OTTHUMP00000042288 p193 PARP 4 PARP related PARP related / IalphaI related H5 / proline rich PARPL PH 5P PH5P Poly (ADP ribose) polymerase 4 Poly (ADP ribose) polymerase family member 4 Poly (ADP ribose) synthetase Poly (ADP ribosyl) transferase like 1 Poly ADP ribose polymerase 4 Poly ADP ribose polymerase family member 4 Vault Vault 3 Vault poly (ADP ribose) polymerase Vault poly ADP ribose polymerase Vault protein 193 kDa Vault3 von Willebrand factor A domain containing 5C VPARP VWA5C
Description Recombinant Human PARP4 Protein was expressed in E.coli. It is a Protein fragment
Source E.coli
Molecular Weight 40 kDa
Purity >= 98% SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Liquid Solution
Stability The recombinant protein samples are stable for up to 12 months at -80°C
Reconstitution See related COA
Unit Definition For Research Use Only
Storage Buffer Shipped at 4°C. Upon delivery aliquot and store at -80°C. Avoid freeze / thaw cycle.

Target Details

Target Function Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Subcellular Location Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle.
Database References
Tissue Specificity Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.

Gene Functions References

  1. Major vault protein is important in the drug resistance of cancer cells, but it requires the presence of vPARP for full activity PMID: 28551640
  2. PARP4 is a possible susceptibility gene of primary thyroid and breast cancer PMID: 26699384
  3. the protein levels of MVP, TEP1 and vPARP are actually increased in the highergrade tumors suggesting existence of post-transcriptional regulation of vault component production. PMID: 23739867
  4. REVIEW:recent findings suggesting that PARP-1 participates in DNA damage signaling in cell death PMID: 12829019


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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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