Name: Recombinant Human NCR3 Protein (Fc Tag)
Brand: Beta LifeScience
SKU: BL-0079NP
Availability: InStock

Catalog No.: BL-0079NP

Product Overview

Tag	Fc
Host Species	Human
Accession	O14931
Synonym	NCR3 Natural Cytotoxicity Triggering Receptor 3; Activating Natural Killer Receptor p30; Natural Killer Cell p30-Related Protein; NK-p30; NKp30; CD337; NCR3; 1C7; LY117
Background	Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed -€œNatural Cytotoxicity Receptors-€. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.
Description	Recombinant Human Natural Cytotoxicity Triggering Receptor 3 is expressed by our Mammalian expression system and the target gene encoding Leu19-Thr138 is expressed with a Fc tag at the C-terminus.
Source	Human Cells
AA Sequence	Leu19-Thr138
Purity	>95% as determined by reducing SDS-PAGE.
Endotoxin	<0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Recombinant Human NCR3 Protein was lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution	Dissolve the lyophilized protein in distilled water.
Usage	For Research Use Only
Storage	Human NCR3 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.